PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT)

Dr. Nurunnahar Kona; Mostafizur Rahman; Tareq Mahmud; Jannatul Adon Khusi; Juairiyah Jahangir; Md. Al Jihad Fillah; Mst. Nusrat Jahan Nisha; Dr. Khadiza Khanom

doi:10.5455/JPPR.20251021093852

Original Article
Online Published: 10 Mar 2026

J Pharmacol Pharm Res. 2026; 3(1): 1-6

doi: 10.5455/JPPR.20251021093852

PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT)

Dr. Nurunnahar Kona, Mostafizur Rahman, Tareq Mahmud, Jannatul Adon Khusi, Juairiyah Jahangir, Md. Al Jihad Fillah, Mst. Nusrat Jahan Nisha, Dr. Khadiza Khanom.

Abstract
Objective:The aim of this work was to use in vivo models to evaluate the analgesic, anti-inflammatory and cytotoxic activities of the combined aqueous extracts of Pandanus foetidus Roxb. Method: Following the extraction by cold extraction process, standard laboratory protocols were used to investigate their analgesic, anti-inflammatory and cytotoxic activity test through acetic acid induced writhing method, carrageenan induced paw edema test and brine shrimp bioassay, respectively. Result:Following the acetic acid induced writher test; 100 mg/kg and 200 mg/kg dose displayed significant analgesic activity with 33.33% and 41.36% writhing inhibition. At the same time, in carrageenan-induced paw edema assay, 100 mg/kg and 200 mg/kg doses produced significant anti-inflammatory effects of 45.33% and 66.21% respectively. The combined plant extract also evaluated for its cytotoxic activity that produces LC50 value of 1020.14μg/ml on brine shrimp nauplii. Conclusion:The results suggest that the analgesic and anti-inflammatory effects of the combined aqueous extracts obtained from Pandanus foetidus operate via a peripheral-mediated mechanism. It can be applicable as a new lead compound for the management of pain and inflammation. This is first time were combine effects of this plant extract has been evaluated.

Key words: Combined extract, analgesic, anti-inflammatory, depressant, cytotoxic

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How to Cite this Article

Pubmed Style

Kona DN, Rahman M, Mahmud T, Khusi JA, Jahangir J, Fillah MAJ, Nisha MNJ, Khanom DK. PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). J Pharmacol Pharm Res. 2026; 3(1): 1-6. doi:10.5455/JPPR.20251021093852

Web Style

Kona DN, Rahman M, Mahmud T, Khusi JA, Jahangir J, Fillah MAJ, Nisha MNJ, Khanom DK. PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). https://www.wisdomgale.com/jppr/?mno=291797 [Access: June 27, 2026]. doi:10.5455/JPPR.20251021093852

AMA (American Medical Association) Style

Kona DN, Rahman M, Mahmud T, Khusi JA, Jahangir J, Fillah MAJ, Nisha MNJ, Khanom DK. PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). J Pharmacol Pharm Res. 2026; 3(1): 1-6. doi:10.5455/JPPR.20251021093852

Vancouver/ICMJE Style

Kona DN, Rahman M, Mahmud T, Khusi JA, Jahangir J, Fillah MAJ, Nisha MNJ, Khanom DK. PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). J Pharmacol Pharm Res. (2026), [cited June 27, 2026]; 3(1): 1-6. doi:10.5455/JPPR.20251021093852

Harvard Style

Kona, D. N., Rahman, . M., Mahmud, . T., Khusi, . J. A., Jahangir, . J., Fillah, . M. A. J., Nisha, . M. N. J. & Khanom, . D. K. (2026) PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). J Pharmacol Pharm Res, 3 (1), 1-6. doi:10.5455/JPPR.20251021093852

Turabian Style

Kona, Dr. Nurunnahar, Mostafizur Rahman, Tareq Mahmud, Jannatul Adon Khusi, Juairiyah Jahangir, Md. Al Jihad Fillah, Mst. Nusrat Jahan Nisha, and Dr. Khadiza Khanom. 2026. PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). Journal of Pharmacological and Pharmaceutical Research, 3 (1), 1-6. doi:10.5455/JPPR.20251021093852

Chicago Style

Kona, Dr. Nurunnahar, Mostafizur Rahman, Tareq Mahmud, Jannatul Adon Khusi, Juairiyah Jahangir, Md. Al Jihad Fillah, Mst. Nusrat Jahan Nisha, and Dr. Khadiza Khanom. "PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT)." Journal of Pharmacological and Pharmaceutical Research 3 (2026), 1-6. doi:10.5455/JPPR.20251021093852

MLA (The Modern Language Association) Style

Kona, Dr. Nurunnahar, Mostafizur Rahman, Tareq Mahmud, Jannatul Adon Khusi, Juairiyah Jahangir, Md. Al Jihad Fillah, Mst. Nusrat Jahan Nisha, and Dr. Khadiza Khanom. "PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT)." Journal of Pharmacological and Pharmaceutical Research 3.1 (2026), 1-6. Print. doi:10.5455/JPPR.20251021093852

APA (American Psychological Association) Style

Kona, D. N., Rahman, . M., Mahmud, . T., Khusi, . J. A., Jahangir, . J., Fillah, . M. A. J., Nisha, . M. N. J. & Khanom, . D. K. (2026) PHARMACOLOGICAL APPLICATIONS OF COMBINED EXTRACT OF PANDANUS FOETIDUSRoxb. (LEAVES AND ROOT). Journal of Pharmacological and Pharmaceutical Research, 3 (1), 1-6. doi:10.5455/JPPR.20251021093852